Severe Acute Gastrointestinal Graft-vs-Host Disease
نویسندگان
چکیده
منابع مشابه
Severe acute gastrointestinal graft-vs-host disease: an emerging surgical dilemma in contemporary cancer care.
OBJECTIVE To determine the natural history of and guidelines for the surgical management of severe acute gastrointestinal (GI) graft-vs-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). DESIGN Case series from a prospective database. SETTING Tertiary care referral center/National Cancer Institute-designated Comprehensive Cancer Center. PATIENTS A total o...
متن کاملAcute graft versus host disease
Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. About 35%-50% of hematopoietic stem cell transplant (HSCT) recipients will develop acute GVHD. The exact risk is...
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(1844 articles) Transplantation (4939 articles) Immunobiology Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Infor...
متن کاملImmunobiology of acute graft-versus-host disease Immunobiology of acute graft-versus-host disease
Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). The immunobiology of acute GVHD is complex and can be conceptualized to be a three-step process. In step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to the damage and activation of host tissues and induces the secretion of inflammator...
متن کاملStool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation
Background Graft-versus-host disease (GVHD) is common after allogeneic hematopoietic cell transplantation (HCT). Risk for death from GVHD has been associated with low bacterial diversity in the stool microbiota early after transplant; however, the specific species associated with GVHD risk remain poorly defined. Methods We prospectively collected serial weekly stool samples from 66 patients w...
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ژورنال
عنوان ژورنال: Archives of Surgery
سال: 2008
ISSN: 0004-0010
DOI: 10.1001/archsurg.143.11.1041